Table 3.
Staphylococcus capitis whole-genome-based studies to determine virulence determinants.
| Date | Ref | Type of Analysis | Genomes | Strain ID | Accession Number | Strain Origin | Putative Genetic Determinants of Pathogenicity | |
|---|---|---|---|---|---|---|---|---|
| 2015 | [46] | Pathogenicity factor search | 1 | AYP1020 | NZ_CP007601.1 | Bacteremia | pAYP1020 | Plasmid |
| - | Prophage | |||||||
| - | Insertion sequence | |||||||
| agr, sar, sae, arl, rot, sigB | Regulation system | |||||||
| ica | Intercellular adhesion factors | |||||||
| cap | Capsule synthesis | |||||||
| hlb | Haemolysin | |||||||
| clp, ssp, sep, htr, spl | Clp protease, cysteine and serine proteases, metalloprotease | |||||||
| lip, geh | Lipase | |||||||
| psm | Phenol-soluble modulins | |||||||
| fbe, aap, ebh, ses, ebp, bhp, sdr | Adhesins/MSCRAMMs | |||||||
| atl | Autolysin | |||||||
| 2014 | [47] | Drug resistance genes | 1 | LNZR-1 | NZ_JGYJ00000000.1 | Bacteremia | - | Presence of multiple genes implicated in drug resistance |
| 2016 | [48] | Pathogenicity factor search | 4 | NRCS-A CR01 CR03 CR04 CR05 |
NZ_CBUB000000000.1 NZ_CVUF00000000.1 NZ_CTEM00000000.1 NZ_CTEO00000000.1 |
Bacteremia | - | Plasmids |
| IS256, IS272, IS431mec-like | Insertion sequences | |||||||
| hsdMSR | Type Restriction/Modification system | |||||||
| - | Presence of multiple genes implicated in drug resistance | |||||||
| atl | Autolysin | |||||||
| ebh, ebp, sdr | Adhesins/MSCRAMMs | |||||||
| ica | Intercellular adhesion factors | |||||||
| clp, ssp, nuc | Clp protease, cysteine and serine protease, nuclease | |||||||
| cap | Capsule synthesis | |||||||
| hlb, hld | Haemolysin | |||||||
| psm | Phenol-soluble modulins | |||||||
| sar, rot, mgr | Regulation system | |||||||
| 2017 | [49] | Pathogenicity factor search | 1 | TE8 | NZ_JMGB00000000.1 | Cutaneous swab | Epidermicin-like and Gallidermin gene clusters | Antimicrobial peptides |
| psm | Phenol-soluble modulins with antimicrobial activities | |||||||