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. 2019 Feb 27;20(5):1042. doi: 10.3390/ijms20051042

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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gPTX-IL suppressed tumor growth in the most effective manner in vivo. gPTX-IL (open circle), gPTX-L (open triangle), naked gPTX (open square), CEP-IL (immunoliposome of CEP solvent) (closed circle), Cremophor EL®, ethanol, and phosphate buffered saline (PBS) (CEP, closed square), or PBS (cross) was intravenously injected at day 0, 4, 8, 12, 16, and 20 (indicated by vertical arrows). (A) The effect of different formulations of gPTX on the volume of tumors. (B) Relative tumor volume at day 30. gPTX-IL was the most effective formulation to suppress the growth of tumor. The statistical significance in mean values of more than two groups was determined using one-way analysis of variance (ANOVA) and Dunnet multiple comparison test using relative tumor volume of gPTX-IL treatment as a control, (*) p < 0.05; (**) p < 0.01; (****) p < 0.001. (C) The tumors from the experiment (A) representing each group were displayed exhibiting the effect of each formulation of gPTX. Data are expressed as the mean with ± SD where n = 4.