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. 2019 Feb 27;20(5):1042. doi: 10.3390/ijms20051042

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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gPTX-IL treatment showed no significance side effects. gPTX- IL (open circle with line), gPTX-L (open triangle), naked gPTX (open square), CEP-IL (closed circle), CEP (closed square), or PBS (cross) was intravenously injected at day 0, 4, 8, 12, 16, and 20 (indicated by vertical arrows). (A) Change of body weight of mice bearing tumors. (B) Relative body weight at day 30. The statistical significance in mean values of more than two groups was determined using one-way analysis of variance (ANOVA) and Dunnet multiple comparison test using relative body weight of PBS treatment as a control, NSD, no significant difference. (C) H & E staining of some vital organs of the drug treated animal groups, each scale bar of liver and kidney section shows 64 µm and spleen section shows 129 µm.