Table 5.

Comparison of ML and B & M results for both scenarios: main barrier located in the lipid and main barrier located in the corneocytes.

Property	Experimental values	Main barrier: lipid		Main barrier: corneocyte
		ML	B & M	ML	B & M
Caffeine
Dlip-lat cm2/s		2.71 × 10−8		2.71 × 10−8
Dcor cm2/s		5.58 × 10−6		1.28 × 10−11
Dlip-trans cm2/s		1 × 10−11
Cv μg/ml	19,465	19,465		19,465
Jss μg/cm2h	2.95 ± 1.5	5.87	5.88	0.22	0.75
kp cm/h	1.516 × 10−4	3 × 10−4	3 × 10−4	1.1 × 10−5	3.84 × 10−5
τ h	2.3 ± 1.5	15	15.1	57.27	16.73
Nicotine
Dlip-lat cm2/s		4.06 × 10−8		4.06 × 10−8
Dcor cm2/s		5.58 × 10−6		1.59 × 10−11
Dlip-trans cm2/s		3 × 10−11
Cv μg/ml	24,000	24,000		24,000
Jss μg/cm2h	130 ± 60	147.18	147.24	4.06	11.34
kp cm/h	5.42 × 10−3	6.13 × 10−3	6.13 × 10−3	1.7 × 10−4	4.73 × 10−4
τ h	1.6 ± 0.5	1.86	1.88	45.57	15.95
DEP
Dlip-lat cm2/s		2.01 × 10−8		2 × 10−8
Dcor cm2/s		4.72 × 10−6		1.09 × 10−11
Dlip-trans cm2/s		1 × 10−11
Cv μg/ml	1019.8	1019.8		1019.8
Jss μg/cm2h	21.0 ± 2.9	15.49	15.49	0.26	1.17
kp cm/h	2.06 × 10−2	1.52 × 10−2	1.52 × 10−2	2.6 × 10−4	1.15 × 10−3
τ h	0.66 ± 0.06	2.01	2.03	70.16	30.34