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. 2019 Feb 26;20(5):1008. doi: 10.3390/ijms20051008

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Agc1^{CreERT2/CreERT2} mice exhibit severe cartilage erosion at 12 months of age. (A) representative images of Safranin O/Fast Green stained knee articular cartilage of 6 and 12 months old Agc1^+/+, Agc1^CreERT2/+ and Agc1^{CreERT2/CreERT2} mice. Arrows indicate severe degeneration of the articular cartilage. Abbreviations: AC, articular cartilage; CZ, calcified zone; SB, subchondral bone. (B) quantification of spontaneous cartilage degeneration using the OARSI scoring system. Bars represent mean ± SD. n = Agc1^+/+: 5(m)/2(f); Agc1^Cre/+: 4(m)/4(f); Agc1^Cre/Cre: 7(m)/2(f) at six months; and n = Agc1^+/+: 6(m)/4(f); Agc1^Cre/+: 7(m)/6(f); Agc1^Cre/Cre: 7(m)/5(f) at 12 months. Statistical significance calculated by one-way ANOVA, where ** p < 0.01.