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. 2019 Feb 26;20(5):1008. doi: 10.3390/ijms20051008

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Analysis of cartilage catabolism. (A) representative immunostaining of MMP-13, ADAMTS-5, VIDIPEN and C1,2C of sections from the articular cartilage at 12 months of age in Agc1^+/+, Agc1^CreERT2/+ and Agc1^{CreERT2/CreERT2}, mice. n = 5 per genotype; (B) C2C ELISA assay in urine of 12-month-old animals. Bars represent mean ± SD. n = Agc1^+/+: 6(m)/4(f); Agc1^Cre/+: 8(m)/4(f); Agc1^Cre/Cre: 7(m)/3(f).