Scheme 3. Scope of Cu-catalysed cross-coupling. The reactions were performed on a 0.3 mmol scale. Conditions: CuI (20 mol%), L3 (20 mol%), aryl boronic acid (1 equiv.), ethyl bromofluoroacetate (2 equiv.), Cs₂CO₃ (2 equiv.), toluene (0.4 M) at 100 °C for 18 h then one-pot hydrolysis with K₂CO₃ (10 equiv.), MeOH/H₂O (1 : 1), 5 h. ^aHydrolysis performed as a subsequent step with K₂CO₃ (5 equiv.). ^bReaction run on 5 mmol scale. All yields are of isolated products.