Table.
Baseline characteristics
| ≤75 years (n=172 321) | >75 years (n=14 483) | ||
|---|---|---|---|
| Age (years) | 61·6 (8·0) | 78·8 (2·8) | |
| Sex | |||
| Male | 125 783 (73%) | 8476 (59%) | |
| Female | 46 538 (27%) | 6007 (41%) | |
| History of vascular disease | 96 088 (56%) | 8034 (55%) | |
| History of myocardial infarction | 59 654 (35%) | 4210 (29%) | |
| History of other symptomatic coronary heart disease | 61 767 (36%) | 4448 (31%) | |
| History of heart failure (New York Heart Association class II–IV)* | 6692 (4%) | 2893 (20%) | |
| On dialysis† | 3546 (2%) | 482 (3%) | |
| History of diabetes | 31 919 (19%) | 2499 (17%) | |
| Current smoker | 35 701 (21%) | 1485 (10%) | |
| Treated hypertension | 82 213 (48%) | 8696 (60%) | |
| Systolic blood pressure (mm Hg) | 138·1 (19·5) | 143·4 (21·4) | |
| Diastolic blood pressure (mm Hg) | 81·2 (10·6) | 78·9 (10·8) | |
| Body–mass index (kg/m2) | 27·1 (24·6–30·1) | 26·3 (23·8–29·1) | |
| Total cholesterol (mmol/L) | 5·4 (1·0) | 5·1 (1·0) | |
| LDL cholesterol (mmol/L) | 3·3 (0·9) | 3·2 (0·8) | |
| HDL cholesterol (mmol/L) | 1·2 (0·3) | 1·3 (0·3) | |
| Triglycerides (mmol/L) | 1·6 (1·2–2·2) | 1·4 (1·0–1·9) | |
| Creatinine (μmol/L)‡ | 94 (80–106) | 99 (88–117) | |
Data are mean SD, n (%), or median (IQR). HOPE-3 participant data for body-mass index (mean 27·2 kg/m2 [SD 4·8] among participants ≤75 years and 26·1 kg/m2 [4·8] among participants >75 years), triglycerides (1·7 mmol/L [1·1] among participants ≤75 years and 1·6 mmol/L [0·9] among participants >75 years), and creatinine (79 μmol/L [19] among participants ≤75 years and 82 μmol/L [20] among participants >75 years) not included. 50 participants with missing age (49 from MEGA and one from A to Z) were excluded.
*
All participants from GISSI-HF and CORONA trials only.
†
All participants from 4D and AURORA trials.
‡
Excludes participants on dialysis at randomisation (ie, participants from 4D and AURORA).