Table 2.

Sequential (sepsis-related) organ failure assessment (SOFA) score.^8,9

System	Score
	0	1	2	3	4
Respiration
PaO2/FIO2, mmHg (kPa)	⩾400 (53.3)	<400 (53.3)	<300 (40)	<200 (26.7) with respiratory support	<100 (13.3) with respiratory support
Coagulation
Platelets, ×103 µL−1	⩾150	<150	<100	<50	<20
Liver
Bilirubin, mg dL−1 (µmol L−1)	<1.2 (20)	1.2–1.9 (20–32)	2.0–5.9 (33–101)	6.0–11.9 (102–204)	>12.0 (204)
Cardiovascular	MAP ⩾ 70 mmHg	MAP < 70 mmHg	Dopamine < 5 or dobutamine (any dose)a	Dopamine 5.1–15 or epinephrine ⩽ 0.1 or norepinephrine ⩽ 0.1a	Dopamine > 15 or epinephrine > 0.1 or norepinephrine > 0.1a
Central Nervous System (CNS)
Glasgow Coma Scale scoreb	15	13–14	10–12	6–9	<6
Renal
Creatinine, mg dL−1 (µmol L−1)	<1.2 (110)	1.2–1.9 (110–170)	2.0–3.4 (171–299)	3.5–4.9 (300–440)	>5.0 (440)
Urine output, mL per day				<500	<200

FIO₂: fraction of inspired oxygen; MAP: mean arterial pressure; PaO₂: partial pressure of oxygen.

^aCatecholamine doses are given as µg kg⁻¹ min⁻¹ for at least 1 h.

^bGlasgow Coma Scale scores range from 3 to 15; higher score indicates better neurological function.