Fig. 1.

NER genes upregulation in MM cells and its prognostic correlation. a Meta-analysis of four different GEP datasets of MM comparing the expression levels of genes belonging to NER DNA-repair pathway in PCs from MM patients with PCs from healthy donors. b Shows a forest plot (on the left) reporting the results of the multivariate COX regression analysis performed on all NER-associated genes and on the 4 prognostic factors included in the R-ISS (B2-microglobulin, albumin, LDH, and adverse cytogenetic). A Kaplan-Meier curve (on the right) reports the results of the prognostic model built by dividing patients into NER “low” and “high” risk groups according to the previously selected genes expression. Importantly, patients in low-risk group experienced a significant hazard ratio reduction of about 70%