Fig. 4.

a Overlap of SNVs and indels: All somatic mutations and indels were classified into three categories: mutations present in all tumor regions (common, blue), mutations shared in more than two but not all regions (shared, green), and mutations in one tumor region (unique, yellow) in each case. The distributions of all somatic mutations in each tumor sample are shown in a stacked bar plot. The number of analyzed mutations is displayed on the right side of each bar. b Comparison of Mut-driver gene mutations: Mutations in 14 Mut-driver genes were detected in all tumor samples, and eight of these were classified as common mutations. A discordant mutation in the PI3K pathway before and after FOLFOX administration was observed in case 2