Fig. 1.

Global tripartite microbial genus-brain connectivity-evoked symptom network. a Demonstrates the global tripartite healthy controls network. b Demonstrates the global tripartite IBS network. c Demonstrates the global tripartite difference network. For clarity, labels related to brain connectivity measures have been omitted from these global networks. 1st Sens first sensation threshold during balloon distension, Disc Thresh discomfort threshold during balloon distension, IBS-SS irritable bowel syndrome–scoring system scores, IV Clostridium IV, LC Disc discomfort during lactulose challenge test, LC Pain pain during lactulose challenge test, OATT oroanal transit time, Pain Thresh pain threshold during balloon distension, Disc Intensity visual analogue scale rating of discomfort during 24 mmHg distension, Pain Intensity visual analogue scale rating of pain during 24 mmHg distension, IBS-SSS IBS Severity Scoring System, XIVa Clostridium XIVa, XIVb Clostridium XIVb, Lachnospiraceae Lachnospiraceae incertae sedis