Fig. 4.

Tripartite Clostridium XIVa subnetwork. a Demonstrates the Clostridium XIVa healthy controls subnetwork. b Demonstrates the Clostridium XIVa IBS subnetwork. c Demonstrates the Clostridium XIVa difference network. Functional brain connectivity of regions of interest is presented with the region of interest noted in a larger font, with the connectivity measure and lateralization indicated below in the form X_Y, where X indicates a connectivity measure (B betweenness centrality, E eigenvector centrality, S degree strength) and Y indicates lateralization (L left, R right). Disc Thresh discomfort threshold during balloon distension, LC Pain pain during lactulose challenge test, OATT oroanal transit time, Pain Thresh pain threshold during balloon distension, Disc Intensity visual analogue scale rating of discomfort during 24 mmHg distension, XIVa Clostridium XIVa, Lachnospiraceae Lachnospiraceae incertae sedis