Table 2.
Subject characteristics and GI sensorimotor function measures
| Healthy controls (N = 21, F = 16) | IBS (N = 65, F = 46) | t | p | |||
|---|---|---|---|---|---|---|
| M | SD | M | SD | |||
| Age | 33.3 | 9.56 | 33.3 | 10.2 | 0.004 | 1.00 |
| Rectal discomfort threshold (mmHg) | 24.4 | 7.1 | 21.2 | 7.8 | 1.66 | 0.10 |
| Rectal pain threshold (mmHg) | 30.5 | 10.3 | 27.4 | 8.8 | 1.33 | 0.19 |
| First rectal sensation (mmHg) | 10.3 | 5.1 | 9.9 | 5.9 | 0.23 | 0.82 |
| IBS-SSS | 26 | 31.3 | 280 | 100 | − 11.36 | 1.15 × 10−18 |
| Rectal discomfort intensity (VAS, mm) | 49.8 | 22.1 | 68.7 | 25.7 | − 3.05 | 0.003 |
| Rectal pain intensity (VAS, mm) | 25.4 | 31.33 | 40.4 | 31.5 | − 2.4 | 0.019 |
| Lactulose challenge—pain (AUC) | 60.7 | 166.41 | 1139.4 | 1243.07 | − 3.95 | 0.0002 |
| Lactulose challenge—discomfort (AUC) | 212.5 | 227.9 | 1911.1 | 1062.2 | − 7.23 | 1.91 × 10− 10 |
| OATT (days) | 1.5 | 0.7 | 1.6 | 1.2 | − 0.26 | 0.84 |