Table 1.

Characteristics of Studies Included

Author	Year	Country	City	Design	HBOC/HBC	Age at Diagnosis (range or mean)	Mutation type	Test type	Sample size	Sample size of HBOC
Abdel-Razeq	2018	Jordan	–	Pilot study	HBCb	22–75	Deleterious Suspected-deleterious	BART1	100	84
Bu	2016	Saudi Arabia	–	Cross-sectional	HBC	41.9	Deleterious	PCR2, CS3/SS4, and TCS5	818	60
Bujassoum	2017	Qatar	–	Retroa	HBC	23–68	Deleterious	MLPA6	82	82
Cherbal	2015	Algeria	High Plains	Cross-sectional	HBOCc	< 50	Deleterious VUS	PCR2	192	192
El Saghir	2015	Lebanon	Beirut	Cross-sectional	HBC	40.8	Deleterious VUS	MLPA6	250	74
Ibrahim	2010	Egypt	Alexandria	Registry data	HBC	43.5	Deleterious	SSCP7 HAC8	60	39
Jalkh	2012	Lebanon	–	Cross-sectional	HBC	41	Deleterious VUS Polymorphisms	Fluorescent DS9	72	72
Kadouri	2007	Palestine	East Jerusalem	Cross-sectional	HBC	–	Deleterious VUS Polymorphisms	DHPLC10	31	10
Laarabi	2017	Morocco	North-East morocco (Rabat, Fes, Oujda)	Cross-sectional	HBOC	–	Deleterious	CSS11 NGS12 TS13	122	122
Laraqui	2013	Morocco	Rabat	Retro	HBC	–	Deleterious	DS14	121	19
Mahfoudh	2012	Tunisia	Sousse	Cross-sectional	HBC	29–65	Deleterious VUS Polymorphisms	DS15	24	24
Riahi	2016	Tunisia	–	Cross-sectional	HBC	–	Deleterious	Logistic regression model (studied three studies)	92	92
Tazzite	2012	Morocco	Casablanca	Case series	HBOC	25–60	Deleterious	DS15	40	34
Uhrhammer	2008	Algeria	Algiers	Pilot study	HBC	15–52	Deleterious VUS Polymorphisms	PCR2	64	13

^aRetro: retrospective cohort study

^bHBC: hereditary breast cancer

^cHBOC: hereditary breast and/or ovarian cancer

¹BART: Comprehensive BRACAnalysis and BRACAnalysis rearrangement test

²PCR: Polymerase chain reaction

³CS: Capture sequencing

⁴SS: Sanger sequencing

⁵TCS: Targeted capture sequencing

⁶MLPA: Multiple ligation dependent probe amplification

⁷SSCP: single strand conformation polymorphism assay

⁸HAC: Heteroduplex assay confirmation

⁹Fluorescent direct sequencing of the entire coding region and intronic sequence flanking each exon

¹⁰DHPLC: denaturing high performance liquid chromatography

¹¹CSS: Conventional individual exon-by-exon Sanger sequencing

¹²NGS: Next generation sequencing

¹³TS: Target screening for exon 10 in BRCA2

¹⁴Direct sequencing of all coding exons and flanking intron sequences of the BRCA1 gene

¹⁵DS: Direct Sequencing

¹⁶Direct sequencing