Table 3.

Summary of baseline and follow-up assessments. The table summarises key assessments carried out at different time points during the study. The participants may undertake any combination of the investigations listed at any of these time points

Time point	Chronic obstructive pulmonary disease		Asthma		Pneumonia		Heart failure		Healthy		Paediatrics
	1	2	1	2	1	2	1	2	1	2	1	2
Written informed consent	x		x		x		x		x		x
Volatile organic compound sampling
ReCIVA – gas chromatography and mass spectrometry	x	x	x	x	x	x	x	x	x	x	x	x
ReCIVA comprehensive two-dimensional gas chromatography	x	x	x	x	x	x	x	x	x	x	x	x
Atmospheric pressure chemical ionisation mass spectrometry	x	x	x	x	x	x	x	x	x	x	x	x
Proton transfer reaction mass spectrometry		x		x		x		x	x	x	x	x
Gas chromatography ion mobility spectrometry	x		x		x		x				x	x
Pathology blood tests
Full blood count (including differential cell count)	x	x	x	x	x	x	x	x	x	x	x	x
Brain natriuretic peptide (pg/mL)	x	x	x		x		x	x	x
Troponin-I (ng/L)	x		x		x		x		x
C reactive protein (mg/L)	x	x	x	x	x	x	x	x	x	x	x	x
Lung function tests
Hand held forced oscillation technique	x	x	x	x	x	x	x	x	x	x
Fractional exhaled nitric oxide – flow rate 50 (mL/s)			x	x							x	x
Spontaneous sputum sample	x	x	x	x	x	x	x	x	x	x
Biobanking (urine, serum, plasma. sputum supernatants and plugs)	x	x	x	x	x	x	x	x	x	x	x	x
Transthoracic echocardiography	x						x