Table 1.
Treatment uncertainties for which consensus that the uncertainty is a research priority was reached
| Treatment uncertainty (research question) | Proportion who rated this question as highly important in the final round | Median (IQR) in the final round |
| What is the best treatment for people with early or very early hepatocellular carcinoma? | 93.5% | 8 (7,9) |
| What are the best treatments that cure or delay the progression (worsening) of primary sclerosing cholangitis (PSC)? | 93.3% | 8 (7,9) |
| What are the best treatments that cure or delay the progression (worsening) of non-alcohol-related fatty liver disease (NAFLD)? | 90.3% | 9 (8,9) |
| What is the best immunosuppressive regimen in adults undergoing liver transplantation? | 90.3% | 8 (7,9) |
| Should general public be educated about NAFLD with an aim to reduce the numbers of those that have it? | 81.8% | 8 (7,9) |
| What are the best treatments that cure or delay the progression (worsening) of autoimmune hepatitis? | 80.6% | 8 (7,9) |
| What are the best treatments that cure or delay the progression (worsening) of non-alcohol-related steatohepatitis? | 76.7% | 8 (6.75,9) |
| Prior to liver transplantation, is it better to transport the donor liver using a machine which pumps blood or preservation solution through the liver (machine perfusion) or is it better to transport it in the standard way of transporting it immersed in cold preservation solution (cold storage)? | 74.2% | 7 (6,9) |
| What are the best treatments that cure or delay the progression (worsening) of primary biliary cholangitis? | 74.2% | 7 (6,8) |
| Are there any treatments that reverse the liver damage in PSC? | 72.4% | 7 (6,9) |