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. Author manuscript; available in PMC: 2019 Mar 22.
Published in final edited form as: Pharmacol Res. 2017 Dec 5;129:515–525. doi: 10.1016/j.phrs.2017.11.036

Figure 4.

Figure 4.

H3R activation enhances A2AR-mediated cAMP signaling in HEK-293 cells. A. Activation of the Gαs-coupled A2AR with its agonist CGS-21680 induced cAMP formation and H3R co-activation enhanced A2AR efficacy. Co-expression of the H3R did not modified the A2AR functional response. Values for pEC50 and maximal effect (Emax) are given in Table 2. B. H3R activation with RAMH decreased forskolin-induced cAMP formation in accord with the inhibitory nature of the Gαi/o-coupled receptor. A2AR expression and receptors co-activation lead to a change in the H3R signaling. Data are means ± SEM from 5 replicates from a representative experiments. Where SEM bars are not visible, they are smaller than the symbol size. Values for pIC50 and maximal effect (Imax) are given in Table 2.