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. Author manuscript; available in PMC: 2019 Mar 22.
Published in final edited form as: Pharmacol Res. 2017 Dec 5;129:515–525. doi: 10.1016/j.phrs.2017.11.036

Figure 6.

Figure 6.

H3R activation decreases A2AR affinity for the agonist CGS-21680 in synaptosomal membranes but not in membranes from the whole striatum A. CGS-21680 (10 and 100 nM) did not modify the H3R affinity for its ligand RAMH in membranes isolated from striatal synaptosomes. B. In the same preparation, the H3R agonist RAMH (100 nM) decreased the A2AR affinity for [3H]-CGS-21680. Values are means ± SEM from 3 replicates from a representative experiment. C. Analysis of 3 independent experiments. The statistical analysis was performed with paired Student’s t test. D. H3R activation with RAMH (100 nM) failed to decreased the A2AR affinity for [3H]-CGS-21680 in membranes from the whole striatum. Values are means ± SEM from 3 replicates from a representative experiment. Where SEM bars are not visible, they are smaller than the symbol size.