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. Author manuscript; available in PMC: 2019 Mar 22.
Published in final edited form as: J Prev Alzheimers Dis. 2018;5(2):110–119. doi: 10.14283/jpad.2018.16

Table 3.

Estimates to the longitudinal rate of change prior to and after symptomatic onset, labeled as “Slope 1” and “Slope 2”, respectively, using all items in the item pool, informative items only, and non-informative items only.

Test Estimates

(SE)		 All items Informative

Items only		 Non-informative

items only
Functional composite

(from the clinical protocol)
 		 Slope 1 0.000375
(0.000211)		 −0.00014
(0.000166)		 0.0000935
(0.000304)
Slope 2 −0.02053
(0.001536)		 −0.02266
(0.001722)		 −0.01624
(0.001308)
Cognitive composite

(from the cognitive battery)
 		 Slope 1 0.000268
(0.000416)		 −0.00177
(0.000469)		 0.002734
(0.000513)
Slope 2 −0.00651
(0.00777)		 −0.01110
(0.001051)		 −0.00315
(0.000636)
Functional and cognitive

composites combined		 Slope 1 −0.00031
(0.000389)		 −0.00242
(0.000430)		 0.002039
(0.000455)
Slope 2 −0.00663
(0.000837)		 −0.01068
(0.001033)		 −0.00290
(0.000652)
*

Slope 1: slope before dementia onset with the first CDR>0 diagnosis; Slope 2: slope after symptomatic onset.