Figure 5.

Chronic overexpression of Ski yields and increase in MMP‐9 secretion over time. P1 cardiac MFB were grown to 70% confluency and were infected with either Ad‐LacZ (MOI of 50) or AdSki (MOI of 50) for various durations up to 96 h. Untreated controls were serum‐deprived, but not infected with either virus. Expression of secreted MMP‐9 was assessed at 24, 48, 72, and 96 h after infection with AdSki. Using mean ± SEM where n = 3, we observed an significant increase in MMP‐9 expression over time, as seen at72 versus 48 h (*P ≤ 0.05) and 96 versus 24 h samples (*P ≤ 0.05).