Figure 2. The transcriptional landscape of mouse dorsal root ganglia (DRG) neurons in both growth-competent and -incompetent states.

DRG neurons have been instrumental in dissecting key molecular mechanisms of axon growth and regeneration failure. Whole transcriptome sequencing of DRG neurons from different stages of axon growth, including a developmental transition from axon growth to synapse formation, a shift from arborizing to elongating growth, and axon regeneration after a peripheral nerve lesion (PNL), has identified novel negative regulators of axon growth and regeneration, thus expanding the number of targets that could be manipulated for therapeutic gain. E, embryonic day.