Table 1.
Demographic profiles and clinical features of 48 patients with Klebsiella pneumoniae meningitis
| Characteristics | Available isolates (n=44) | P-value (hvKP vs non-hvKP) | ||
|---|---|---|---|---|
| Total (n=48) | hvKP (n=22) | Non-hvKP (n=22) | ||
| Demographic data | ||||
| Age (years), mean (± SD) | 50.3±16.0 | 55.2±13.4 | 48.3±17.6 | 0.15 |
| Male, n (%) | 30 (62.5) | 13 (59.1) | 16 (72.2) | 0.34 |
| Acquired infection model, n (%) | ||||
| Community-acquired infection | 3 (6.3) | 1 (4.5) | 1 (4.5) | 1.00 |
| Hospital-acquired infection | 45 (93.8) | 21 (95.5) | 21 (95.5) | 1.00 |
| Types of infection, n (%) | ||||
| Spontaneous meningitis | 3 (6.3) | 1 (4.5) | 1 (4.5) | 1.00 |
| Postneurosurgical/post-trauma meningitis | 45 (93.8) | 21 (95.5) | 21 (95.5) | 1.00 |
| Comorbidity, n (%) | ||||
| Diabetes mellitus | 10 (20.8) | 5 (22.7) | 5 (22.7) | 1.00 |
| Hypertension | 14 (29.2) | 6 (27.3) | 8 (36.4) | 0.52 |
| Brain tumor | 12 (25.0) | 4 (18.2) | 6 (27.3) | 0.47 |
| Head trauma | 18 (37.5) | 9 (40.9) | 9 (40.9) | 1.00 |
| Intracerebral hemorrhage | 15 (31.3) | 7 (31.8) | 8 (36.4) | 0.75 |
| Extrameningeal infection, n (%) | ||||
| Bacteremia | 17 (35.4) | 9 (40.9) | 7 (31.8) | 0.53 |
| Pneumonia | 18 (37.5) | 11 (50.0) | 7 (31.8) | 0.22 |
| Liver abscess | 1 (2.1) | 1 (4.5) | 0 (0.0) | 1.00 |
| Brain abscess | 2 (4.2) | 1 (4.5) | 0 (0.0) | 1.00 |
| Chronic otitis media | 1 (2.1) | 0 (0.0) | 0 (0.0) | – |
| CSF profiles, median (IQR) | ||||
| RBC count (per µL) | 150 (20.0–862.5) | 50 (155.0–1,500.0) | 10 (95.0–962.5) | 0.46 |
| WBC count (per µL) | 900 (72.5–6,265.0) | 60 (210–3,050.0) | 140 (1,040.0–9,100.0) | 0.41 |
| Sugar (mmol/L) | 0.6 (0.1–2.9) | 0.1 (0.4–2.9) | 0.1 (0.5–2.7) | 0.88 |
| Chlorine (mmol/L) | 112 (105.5–119.8) | 106.5 (112.0–120.8) | 106.5 (111.5–118.5) | 0.66 |
| Protein (g/L) | 2.7 (1.7–6.1) | 1.6 (2.7–7.2) | 1.6 (3.0–5.7) | 0.98 |
| 30-day mortality, n (%) | 30 (62.5) | 17 (77.3) | 12 (54.5) | 0.11 |
Abbreviations: CSF, cerebrospinal fluid; hvKP, hypervirulent K. pneumoniae; RBC, red blood cell; WBC, while blood cell.