Table 2.

Clinical features of 15 patients with KPC-2-producing hvKP meningitis

Patient no.	Strain ID	Age (years)	Sex	Unit	Comorbidity	Neurosurgical procedures	Treatment	Outcome
1	KP11	68	F	ICU	Severe pneumonia, bacteremia	Yes	MRP	Died
2	KP17	27	F	Surgery	ICH, pneumonia, bacteremia	Yes	MRP, MXF	Died
3	KP21	41	M	ICU	Head trauma, pneumonia, bacteremia	Yes	MRP, TGC	Died
4	KP22	63	F	Surgery	SAH, hypertension, pneumonia	Yes	MRP, LEV, AMI	Died
5	KP25	38	M	Surgery	Head trauma, pneumonia	Yes	MRP, C/S, PXE	Died
6	KP27	67	M	ICU	Meningioma, DM, heart disease	Yes	MRP	Died
7	KP31	67	M	ICU	Cerebral infarction, DM, COPD	No	C/S, TGC	Died
8	KP33	53	M	Surgery	AVM rupture, pneumonia	Yes	MRP, TGC	Died
9	KP35	58	M	Surgery	Head trauma, SDH, bacteremia	Yes	MRP, TGC, C/S	Died
10	KP36	67	F	ICU	SAH, hypertension, pneumonia	Yes	TGC, C/S	Died
11	KP37	63	M	ICU	ICH, Alzheimer disease, hypertension, pneumonia, bacteremia	Yes	MRP, TGC	Died
12	KP38	46	M	Surgery	Head trauma, renal calculus	Yes	MRP, TGC	Died
13	KP41	80	F	ICU	SAH, DM, heart disease, pneumonia	Yes	C/S	Died
14	KP43	72	M	ICU	Head trauma, hypertension, pneumonia, bacteremia	Yes	C/S, TGC, PXE	Died
15	KP44	52	F	Surgery	Hydrocephalus, pneumonia	Yes	MRP, TGC, C/S	Died

Abbreviations: AMI, amikacin; AVM, arteriovenous malformation; C/S, cefoperazone/sulbactam; DM, diabetes mellitus; F, female; hvKP, hypervirulent Klebsiella pneumoniae; ICH, intracerebral hemorrhage; ICU, intensive care unit; KPC-2, K. pneumoniae carbapenemase-2; LEV, levofloxacin; M, male; MRP, meropenem; MXF, moxifloxacin; PXE, polymyxin E; SAH, subarachnoid hemorrhage related to a brain aneurysm; SDH, subdural hemorrhage; TGC, tigecycline.