Fig. 2.

Effect of the i.p. administration of chalcone (1), 5′-methyl-2′-hydroxychalcone (9), 4′-aminochalcone (14), 4′-methylchalcone (15), 3-nitrochalcone (16) (10 mg/kg) and DZ (1 mg/kg, inset) in mice in the plus maze test. Results are expressed as mean ± S.E.M. of total arm entries, percentage of open arm entries and percentage of time spent in open arms; registered in 5 min sessions. The symbols denote significance levels: **P < 0.01, ***P < 0.001, significantly different from vehicle (VEH); Dunnett's multiple comparison test after one-way ANOVA (n = 6–32 mice per group).