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. 2019 Mar 19;5(3):e01376. doi: 10.1016/j.heliyon.2019.e01376

Fig. 4.

Fig. 4

Effect of acute administration of chalcone (1), 6′-methoxy-2′-hydroxychalcone (5) and IMP (reference drug) in the tail suspension test in mice. A) Effect of i.p. injection of chalcone (1), 6′-methoxy-2′-hydroxychalcone (5) (10 mg/kg) and IMP (30 mg/kg) (n = 8–21 mice per group). B) Effect of chalcone 1 (3, 10 and 30 mg/kg) (n = 8–11 mice per group). C) Effect of chalcone 1 (10 and 30 mg/kg) in the locomotor activity tests in mice (n = 6–13 mice per group). Results are expressed as mean ± S.E.M. of the immobility time (in s) and spontaneous locomotor activity counts; registered in 5 min sessions. Statistical analysis was performed by one-way ANOVA followed by Dunnett's test. ***P < 0.001, *P < 0.05, **P < 0.01, significantly different from vehicle (VEH).