Table 2.

Molecular structures of the chalcones.

	Compound	R2’	R3’	R4’	R5’	R6’	R2	R3	R4	R5	R6	cLog P
1	Chalcone	H	H	H	H	H	H	H	H	H	H	3.59
2	2′-hydroxychalcone	OH	H	H	H	H	H	H	H	H	H	3.20
3	4′-methoxy-2′-hydroxychalcone	OH	H	OCH3	H	H	H	H	H	H	H	3.07
4	5′-methoxy-2′-hydroxychalcone	OH	H	H	OCH3	H	H	H	H	H	H	3.07
5	6′-methoxy-2′-hydroxychalcone	OH	H	H	H	OCH3	H	H	H	H	H	3.07
6	5′-chloro-2′-hydroxychalcone	OH	H	H	Cl	H	H	H	H	H	H	3.75
7	5′-fluoro-2′-hydroxychalcone	OH	H	H	F	H	H	H	H	H	H	3.35
8	5′-bromo-2′-hydroxychalcone	OH	H	H	Br	H	H	H	H	H	H	4.02
9	5′-methyl-2′-hydroxychalcone	OH	H	H	CH3	H	H	H	H	H	H	3.68
10	3′,5′-dibromo-2′-hydroxychalcone	OH	Br	H	Br	H	H	H	H	H	H	4.85
11	4′,5′-dimethyl-2′-hydroxychalcone	OH	H	CH3	CH3	H	H	H	H	H	H	4.17
12	5′-methyl-2′-hydroxy-3′-nitrochalcone	OH	NO2	H	CH3	H	H	H	H	H	H	3.34
13	3′-methoxy-4′-hydroxychalcone	H	OCH3	OH	H	H	H	H	H	H	H	3.07
14	4′-aminochalcone	H	H	NH2	H	H	H	H	H	H	H	2.78
15	4′-methylchalcone	H	H	CH3	H	H	H	H	H	H	H	4.07
16	3-nitrochalcone	H	H	H	H	H	H	NO2	H	H	H	3.31
17	4-nitrochalcone	H	H	H	H	H	H	H	NO2	H	H	3.31
18	3-chlorochalcone	H	H	H	H	H	H	Cl	H	H	H	4.14
19	4-chlorochalcone	H	H	H	H	H	H	H	Cl	H	H	4.14
20	4-dimethylaminochalcone	H	H	H	H	H	H	H	N(CH3)2	H	H	3.87
21	4′-amino-3-nitrochalcone	H	H	NH2	H	H	H	NO2	H	H	H	2.50

R₂’, R₃’, R₄’, R₅’, R₆’, R₂, R₃, R₄, R₅, R₆ represent the substituent as indicated in chalcone structure from Fig. 1.