Figure 2.

Localization of mesenchymal stromal cell (MSC)/pericyte markers in MS and healthy control brain tissue. Immunohistochemical staining of serial sections for MSC/pericyte markers localized to the perivascular regions in the adult healthy control brain in chronic active lesions from EPMS and LPMS, as well as healthy tissues (representative images of disease status across all donors). CD73, CD271, and PDGFRβ were found typically within the adventitial layer and perivascular tissue, whereas pericyte markers CD146 and PDGFRβ were localized abluminally to endothelial cells. Scale bars = 20 µm. Abbreviations: EPMS, early progressive MS; LPMS, late stage progressive MS; PDGFRβ, platelet‐derived growth factor receptor beta.