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. 2017 Oct 5;6(11):1987–1996. doi: 10.1002/sctm.17-0074

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© 2017 The Authors stem cells translational medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Effects of HUCBC and ECFC administration on neuronal survival (A), astrogliosis (B), and capillary density (C) 7 days (a, c) and 12 weeks (b, d) after neonatal HI. Representative NeuN immunofluorescence (red) at P14 (Aa) and W12 (Ac), Representative glial fibrillary acidic protein (GFAP) immunofluorescence (green) at P14 (Ba) and W12 (Bc) and Representative eNOS immunofluorescence (red) at P14 (Ca) and W12 (Cc). Ipsilateral/contralateral ratio of NeuN‐immunopositive cells at P14 (Ab) and W12 (Ad), ipsilateral/contralateral ratio of GFAP‐immunopositive cells at P14 (Bb) and W12 (Bd) and ipsilateral/contralateral ratio of eNOS‐immunopositive cells at P14 (Cb) and W12 (Cd), (mean ± SD; *, p < .05 compared with Control; **, p < .01 compared with Control, n =5 in each group; unpaired t test followed by post hoc Bonferroni test; scale bars = 20 µm). Abbreviations: ECFC, endothelial colony‐forming cells; HUCBC, human umbilical cord blood cells.