Table 7.
Gene Ontology annotation analysis
| MicroRNA | Category | ID | Term | P-value | Fold enrichment |
|---|---|---|---|---|---|
| hsa-mir-16-2 | Biological process | GO:0032774 | RNA biosynthetic process | 3.31E-02 | 1.82 |
| GO:0010556 | Regulation of macromolecule biosynthetic process | 4.31E-05 | 1.77 | ||
| GO:2000112 | Regulation of cellular macromolecule biosynthetic process | 2.76E-04 | 1.74 | ||
| GO:0051252 | Regulation of RNA metabolic process | 8.69E-04 | 1.73 | ||
| GO:1903506 | Regulation of nucleic acid-templated transcription | 3.70E-03 | 1.72 | ||
| GO:2001141 | Regulation of RNA biosynthetic process | 4.09E-03 | 1.71 | ||
| GO:0006355 | Regulation of transcription, DNA-templated | 5.83E-03 | 1.71 | ||
| GO:0009889 | Regulation of biosynthetic process | 2.13E-04 | 1.7 | ||
| GO:0019219 | Regulation of nucleobase-containing compound metabolic process | 7.37E-04 | 1.69 | ||
| GO:0031326 | Regulation of cellular biosynthetic process | 4.32E-04 | 1.69 | ||
| GO:0048523 | Negative regulation of cellular process | 6.20E-04 | 1.68 | ||
| GO:0048519 | Negative regulation of biological process | 1.52E-03 | 1.61 | ||
| GO:0051171 | Regulation of nitrogen compound metabolic process | 1.02E-04 | 1.58 | ||
| GO:0060255 | Regulation of macromolecule metabolic process | 7.20E-05 | 1.57 | ||
| GO:0010468 | Regulation of gene expression | 2.39E-02 | 1.57 | ||
| GO:0080090 | Regulation of primary metabolic process | 1.22E-04 | 1.57 | ||
| GO:0031323 | Regulation of cellular metabolic process | 2.27E-04 | 1.55 | ||
| GO:0048856 | Anatomical structure development | 3.73E-02 | 1.51 | ||
| GO:0019222 | Regulation of metabolic process | 7.13E-04 | 1.5 | ||
| Cellular component | GO:0005634 | Nucleus | 4.54E-06 | 1.52 | |
| Molecular function | GO:0003700 | Transcription factor activity, sequence-specific DNA binding | 1.11E-02 | 2.29 | |
| GO:0001071 | Nucleic acid binding transcription factor activity | 1.13E-02 | 2.29 | ||
| GO:0003677 | DNA binding | 1.48E-02 | 1.83 | ||
| GO:0046872 | Metal ion binding | 1.88E-05 | 1.77 | ||
| GO:0043169 | Cation binding | 5.41E-05 | 1.73 | ||
| GO:0043167 | Ion binding | 5.96E-04 | 1.51 | ||
| hsa-mir-31 | Biological process | GO:0042325 | Regulation of phosphorylation | 4.93E-02 | 2.57 |
| GO:0031325 | Positive regulation of cellular metabolic process | 7.67E-03 | 2.07 | ||
| GO:0051173 | Positive regulation of nitrogen compound metabolic process | 4.79E-02 | 2.01 | ||
| GO:0009893 | Positive regulation of metabolic process | 2.07E-02 | 1.98 | ||
| GO:0048522 | Positive regulation of cellular process | 3.44E-05 | 1.93 | ||
| GO:0048518 | Positive regulation of biological process | 2.12E-06 | 1.92 | ||
| GO:0051171 | Regulation of nitrogen compound metabolic process | 5.65E-03 | 1.67 | ||
| GO:0060255 | Regulation of macromolecule metabolic process | 3.60E-03 | 1.67 | ||
| GO:0031323 | Regulation of cellular metabolic process | 4.80E-03 | 1.66 | ||
| GO:0080090 | Regulation of primary metabolic process | 7.25E-03 | 1.65 | ||
| GO:0019222 | Regulation of metabolic process | 4.29E-03 | 1.62 | ||
| hsa-mir-484 | Biological process | GO:0048666 | Neuron development | 3.68E-02 | 2.48 |
| GO:0010557 | Positive regulation of macromolecule biosynthetic process | 1.00E-03 | 2.08 | ||
| GO:0031328 | Positive regulation of cellular biosynthetic process | 2.42E-03 | 2 | ||
| GO:0010628 | Positive regulation of gene expression | 3.84E-03 | 1.99 | ||
| GO:0051254 | Positive regulation of RNA metabolic process | 4.90E-02 | 1.98 | ||
| GO:0009891 | Positive regulation of biosynthetic process | 4.15E-03 | 1.97 | ||
| GO:0045935 | Positive regulation of nucleobase-containing compound metabolic process | 9.25E-03 | 1.96 | ||
| GO:0010604 | Positive regulation of macromolecule metabolic process | 4.02E-05 | 1.84 | ||
| GO:0051173 | Positive regulation of nitrogen compound metabolic process | 4.58E-04 | 1.79 | ||
| GO:0031325 | Positive regulation of cellular metabolic process | 2.55E-04 | 1.79 | ||
| GO:0009893 | Positive regulation of metabolic process | 8.18E-05 | 1.78 | ||
| GO:0009892 | Negative regulation of metabolic process | 1.73E-03 | 1.77 | ||
| GO:0031324 | Negative regulation of cellular metabolic process | 8.96E-03 | 1.77 | ||
| GO:0010605 | Negative regulation of macromolecule metabolic process | 4.78E-02 | 1.71 | ||
| GO:0048869 | Cellular developmental process | 3.51E-02 | 1.57 | ||
| GO:0048731 | System development | 8.96E-03 | 1.55 | ||
| GO:0048523 | Negative regulation of cellular process | 5.89E-03 | 1.54 | ||
| GO:0048522 | Positive regulation of cellular process | 1.07E-03 | 1.54 | ||
| GO:0007275 | Multicellular organism development | 2.81E-03 | 1.53 | ||
| Cellular component | GO:0005667 | Transcription factor complex | 8.69E-03 | 3.49 | |
| GO:0043234 | Protein complex | 6.53E-04 | 1.68 | ||
| GO:0032991 | Macromolecular complex | 3.60E-05 | 1.56 | ||
| Molecular function | GO:0043565 | Sequence-specific DNA binding | 1.34E-02 | 2.23 |