Table 8.
KEGG and PANTHER analyses
| MicroRNA | Term | Database | ID | Input number | Background number | P-value |
|---|---|---|---|---|---|---|
| hsa-mir-16-2 | Circadian rhythm | KEGG pathway | hsa04710 | 4 | 30 | 0.000365555 |
| MAPK signaling pathway | KEGG pathway | hsa04010 | 8 | 257 | 0.005579127 | |
| Gap junction | KEGG pathway | hsa04540 | 4 | 88 | 0.014007203 | |
| ALS | KEGG pathway | hsa05014 | 3 | 51 | 0.017107832 | |
| Progesterone-mediated oocyte maturation | KEGG pathway | hsa04914 | 4 | 97 | 0.019095593 | |
| Glycosaminoglycan biosynthesis – heparan sulfate/heparin | KEGG pathway | hsa00534 | 2 | 25 | 0.029980769 | |
| Long-term potentiation | KEGG pathway | hsa04720 | 3 | 66 | 0.032404978 | |
| Renal cell carcinoma | KEGG pathway | hsa05211 | 3 | 69 | 0.036094866 | |
| Dorsoventral axis formation | KEGG pathway | hsa04320 | 2 | 28 | 0.036434645 | |
| Oocyte meiosis | KEGG pathway | hsa04114 | 4 | 120 | 0.036784673 | |
| Neurotrophin signaling pathway | KEGG pathway | hsa04722 | 4 | 122 | 0.038652503 | |
| Thyroid hormone synthesis | KEGG pathway | hsa04918 | 3 | 71 | 0.03866969 | |
| Antigen processing and presentation | KEGG pathway | hsa04612 | 3 | 71 | 0.03866969 | |
| RNA degradation | KEGG pathway | hsa03018 | 3 | 77 | 0.046937327 | |
| FAS signaling pathway | PANTHER | P00020 | 3 | 31 | 0.004779418 | |
| Integrin signaling pathway | PANTHER | P00034 | 6 | 166 | 0.008045548 | |
| Cadherin signaling pathway | PANTHER | P00012 | 5 | 154 | 0.022562161 | |
| FGF signaling pathway | PANTHER | P00021 | 4 | 103 | 0.023047641 | |
| Heterotrimeric G-protein signaling pathway – Gi alpha and Gs alpha-mediated pathway | PANTHER | P00026 | 5 | 157 | 0.02421771 | |
| Apoptosis signaling pathway | PANTHER | P00006 | 4 | 108 | 0.026693923 | |
| CCKR signaling map | PANTHER | P06959 | 5 | 176 | 0.036514088 | |
| hsa-mir-31 | Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway | PANTHER | P00027 | 4 | 121 | 0.037711913 |
| Hippo signaling pathway | KEGG pathway | hsa04390 | 5 | 153 | 0.00249984 | |
| Oxytocin signaling pathway | KEGG pathway | hsa04921 | 5 | 160 | 0.003013067 | |
| Melanogenesis | KEGG pathway | hsa04916 | 4 | 100 | 0.003392532 | |
| Sphingolipid signaling pathway | KEGG pathway | hsa04071 | 4 | 123 | 0.006872453 | |
| AMPK signaling pathway | KEGG pathway | hsa04152 | 4 | 125 | 0.007255462 | |
| Dopaminergic synapse | KEGG pathway | hsa04728 | 4 | 129 | 0.008063183 | |
| Proteoglycans in cancer | KEGG pathway | hsa05205 | 5 | 208 | 0.008756401 | |
| Ubiquitin-mediated proteolysis | KEGG pathway | hsa04120 | 4 | 137 | 0.009850899 | |
| Wnt signaling pathway | KEGG pathway | hsa04310 | 4 | 142 | 0.011089117 | |
| Circadian rhythm | KEGG pathway | hsa04710 | 2 | 30 | 0.015281252 | |
| cGMP-PKG signaling pathway | KEGG pathway | hsa04022 | 4 | 173 | 0.021002596 | |
| Axon guidance | KEGG pathway | hsa04360 | 4 | 178 | 0.022982044 | |
| Calcium signaling pathway | KEGG pathway | hsa04020 | 4 | 179 | 0.023391098 | |
| Glucagon signaling pathway | KEGG pathway | hsa04922 | 3 | 102 | 0.024384407 | |
| T-cell receptor signaling pathway | KEGG pathway | hsa04660 | 3 | 107 | 0.02748699 | |
| Insulin resistance | KEGG pathway | hsa04931 | 3 | 111 | 0.030113491 | |
| Oocyte meiosis | KEGG pathway | hsa04114 | 3 | 120 | 0.036489064 | |
| Neurotrophin signaling pathway | KEGG pathway | hsa04722 | 3 | 122 | 0.037992724 | |
| Vascular smooth muscle contraction | KEGG pathway | hsa04270 | 3 | 123 | 0.038756301 | |
| ALS | KEGG pathway | hsa05014 | 2 | 51 | 0.039184796 | |
| Natural killer cell-mediated cytotoxicity | KEGG pathway | hsa04650 | 3 | 130 | 0.044318798 | |
| Basal cell carcinoma | KEGG pathway | hsa05217 | 2 | 55 | 0.044700392 | |
| FGF signaling pathway | PANTHER | P00021 | 5 | 103 | 0.000457823 | |
| EGF receptor signaling pathway | PANTHER | P00018 | 5 | 114 | 0.000712265 | |
| Angiogenesis | PANTHER | P00005 | 5 | 161 | 0.003092145 | |
| Endothelin signaling pathway | PANTHER | P00019 | 3 | 79 | 0.012699626 | |
| T-cell activation | PANTHER | P00053 | 3 | 79 | 0.012699626 | |
| CCKR signaling map | PANTHER | P06959 | 4 | 176 | 0.022177133 | |
| Apoptosis signaling pathway | PANTHER | P00006 | 3 | 108 | 0.028131602 | |
| Alzheimer disease – presenilin pathway | PANTHER | P00004 | 3 | 112 | 0.030790107 | |
| Lonotropic glutamate receptor pathway | PANTHER | P00037 | 2 | 46 | 0.03269137 | |
| Wnt signaling pathway | PANTHER | P00057 | 5 | 295 | 0.032927779 | |
| Inflammation mediated by chemokine and cytokine signaling pathway | PANTHER | P00031 | 4 | 202 | 0.034033451 | |
| Oxytocin receptor mediated signaling pathway | PANTHER | P04391 | 2 | 55 | 0.044700392 | |
| Thyrotropin-releasing hormone receptor signaling pathway | PANTHER | P04394 | 2 | 57 | 0.047559619 | |
| hsa-mir-484 | Wnt signaling pathway | KEGG pathway | hsa04310 | 8 | 142 | 0.000852343 |
| HTLV-I infection | KEGG pathway | hsa05166 | 11 | 259 | 0.000948874 | |
| Cytokine–cytokine receptor interaction | KEGG pathway | hsa04060 | 11 | 265 | 0.001132924 | |
| Adherens junction | KEGG pathway | hsa04520 | 5 | 74 | 0.003864995 | |
| Hippo signaling pathway | KEGG pathway | hsa04390 | 7 | 153 | 0.005339916 | |
| Jak-STAT signaling pathway | KEGG pathway | hsa04630 | 7 | 160 | 0.006710057 | |
| Endometrial cancer | KEGG pathway | hsa05213 | 4 | 54 | 0.00710104 | |
| Hippo signaling pathway – multiple species | KEGG pathway | hsa04392 | 3 | 28 | 0.007685262 | |
| Axon guidance | KEGG pathway | hsa04360 | 7 | 178 | 0.011418848 | |
| VEGF signaling pathway | KEGG pathway | hsa04370 | 4 | 64 | 0.012312511 | |
| CAMs | KEGG pathway | hsa04514 | 6 | 143 | 0.014087791 | |
| SNARE interactions in vesicular transport | KEGG pathway | hsa04130 | 3 | 36 | 0.014469204 | |
| PPAR signaling pathway | KEGG pathway | hsa03320 | 4 | 73 | 0.018678443 | |
| Melanoma | KEGG pathway | hsa05218 | 4 | 73 | 0.018678443 | |
| PI3K-Akt signaling pathway | KEGG pathway | hsa04151 | 10 | 343 | 0.018921484 | |
| Protein processing in endoplasmic reticulum | KEGG pathway | hsa04141 | 6 | 167 | 0.027083189 | |
| ECM-receptor interaction | KEGG pathway | hsa04512 | 4 | 83 | 0.027778622 | |
| RNA transport | KEGG pathway | hsa03013 | 6 | 171 | 0.029828233 | |
| N-glycan biosynthesis | KEGG pathway | hsa00510 | 3 | 49 | 0.030909326 | |
| Hematopoietic cell lineage | KEGG pathway | hsa04640 | 4 | 86 | 0.030942 | |
| Mismatch repair | KEGG pathway | hsa03430 | 2 | 23 | 0.042292382 | |
| Insulin signaling pathway | KEGG pathway | hsa04910 | 5 | 141 | 0.043874311 | |
| Pathways in cancer | KEGG pathway | hsa05200 | 10 | 399 | 0.044847988 | |
| Acute myeloid leukemia | KEGG pathway | hsa05221 | 3 | 59 | 0.048121632 | |
| Angiogenesis | PANTHER | P00005 | 7 | 161 | 0.006925275 | |
| Wnt signaling pathway | PANTHER | P00057 | 10 | 295 | 0.007391165 | |
| Pyrimidine metabolism | PANTHER | P02771 | 2 | 10 | 0.01040345 | |
| Axon guidance mediated by netrin | PANTHER | P00009 | 3 | 32 | 0.010767727 | |
| Blood coagulation | PANTHER | P00011 | 3 | 38 | 0.016557181 | |
| Axon guidance mediated by semaphorins | PANTHER | P00007 | 2 | 19 | 0.030634121 |
Abbreviations: ALS, amyotrophic lateral sclerosis; AMPK, AMP-activated protein kinase; CAM, cell adhesion molecule; CCKR, cholecystokinin receptor; cGMP-PKG, cyclic guanosine monophosphate-dependent protein kinase G; ECM, extracellular matrix; EGF, epidermal growth factor; FAS, fatty acid synthase; FGF, fibroblast growth factor; HTLV-I, human T-cell lymphotropic virus I; Jak-STAT, janus kinase–STAT; KEGG, Kyoto Encyclopedia of Genes and Genomes; MAPK, mitogen-activated protein kinase; PPAR, peroxisome-proliferator-activated receptor; VEGF, vascular endothelial growth factor.