Figure 2: Sequence and structural views of RGS proteins.
(A) Sequence alignment of RGS4, RGS8, and RGS19 is shown with conserved residues highlighted in red; blue boxes indicate residues that are conserved between at least two among three RGS proteins. (B) Shown are front and back views of the overlay of RGS4 (PDB code 1AGR), RGS8 (PDB code 2ODE), and RGS19 (PDB code 1CMZ) structures with each of the nine helices uniquely colored. Regions rendered as white cartoons are interhelical loops.