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. Author manuscript; available in PMC: 2019 Sep 6.
Published in final edited form as: Nature. 2019 Mar 6;567(7747):249–252. doi: 10.1038/s41586-019-1004-y

Figure 3 |. STAT3 signaling in hepatocytes orchestrates the formation of a pro-metastatic niche in the liver.

Figure 3 |

a, Study design for b-f (n = 4 for Stat3flox/flox mice injected with PBS or PDAC cells; n = 8 and 7 for Stat3flox/flox Alb-Cre mice injected with PBS or PDAC cells, respectively). b, c, Quantification of pSTAT3+ cells, myeloid cells, and FN. d, mRNA levels of Saa in the liver. e, Images of Saa. Dashed lines and asterisks indicate sinusoids and hepatocytes. f, Concentration of circulating SAA. Data representative of two independent experiments (a-f). Scale bars, 50 μm. Statistical significance was calculated using one-way ANOVA with Dunnett’s test. Data represented as mean ± s.d.