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. Author manuscript; available in PMC: 2019 Mar 22.
Published in final edited form as: Nature. 2018 Jul 18;559(7715):637–641. doi: 10.1038/s41586-018-0350-5

Fig. 4 |. Hyperglycaemia promotes xenografted tumour growth, which is suppressed by TET2 and further prevented by metformin.

Fig. 4 |

a, b, Representative images of tumour-bearing diabetic (a) and nondiabetic (b) nude mice xenografted with A2058-TET2WT (left) or mock tumour cells (right) treated with (+) or without (−) metformin. c, d, Quantitative comparison of tumour size and efficacy of metformin’s tumour suppressive function on A2058-TET2WT and mock tumours in diabetic (c) and non-diabetic (d) nude mice. c, n = 5, ***P = 8.3 × 10−4 (TET2 versus mock), *P = 0.048 (TET2 versus TET2 + Met). d, n = 4–5, ****P = 5.2 × 10−6 (TET2 versus mock), 0.0046 (TET2 versus TET2 + Met). Two-sided Student’s t-test, data shown as mean ± s.e.m. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; NS, not significant.