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. 2019 Jan 11;27(2):134–144. doi: 10.4062/biomolther.2018.175

Fig. 7.

Fig. 7.

Retinol metabolism pathway altered in CKOHF compared to WTHF. The bar graphs represent that all-trans-5,6-epoxy-retinoic acid, all-trans-4-hydroxy-retinoic acid and all-trans-4-oxo-retinoic acid were significantly different between WTHF and CKOHF (q<0.1). all-trans-Retinoic acid was not significant but increased. Gene expression shown in pink boxes represent cyp3a41b was found highly up-regulated (FC threshold=1.5) in CKOHF compared to WTHF. cyp26a1 was also up-regulated but not within the criteria (FC threshold=1.5). m/z values of all-trans-5,6-epoxy-retinoic acid is identical to all-trans-4-hydroxy-retinoic acid. *q<0.1, **q<0.05, ns=not significant.