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. 2019 Feb 8;27(2):178–184. doi: 10.4062/biomolther.2018.234

Fig. 3.

Fig. 3.

β-LAP upregulated the expression of HO-1 in striatal astrocytes. (A) Quantitative real-time PCR data showing the mRNA expression of HO-1 in striatum of MPTP-injected mice (n=5 per group). (B) Western blot analysis showing the expression of HO-1 protein in the striatum of MPTP-injected mice (n=5 per group). The quantification data are provided in the right panel. (C) The double IF staining results indicate that the HO-1 protein (green) was upregulated by MPTP in striatal astrocytes that were labeled with GFAP (red), and combined treatment of β-LAP with MPTP increased the HO-1 expression level. The white arrows indicate the cells that are positive for both GFAP and HO-1. (D) The quantification data showing the proportion of GFAP/HO-1-positive cells to GFAP only-positive cells. *p<0.05 vs. the control group; #p<0.05 vs. the MPTP group.