Fig. 4.

β-LAP activated the p-AMPK and Nrf2 signaling pathways in the striatum of MPTP-injected mice. (A) The protein samples from the striatum of each group were subjected to western blot analyses using antibodies against phospho-form of AMPK, and the level of p-AMPK was normalized to that of β-actin (n=5 per group). (B) The level of Nrf2 protein in the nuclear fractions of the striatum was determined by western blot analysis (n=3 per group). The quantification data are provided in the right panel. (C) EMSA was performed using nuclear extracts isolated from the striatum of each group (n=3 per group). The bracket indicates ARE+nuclear protein complex. ‘F’ indicates a free probe. ^#p<0.05 vs. the MPTP group.