Table 6.
Uni- and multivariate analysis of factors to predict occurrence of a decrease (minimally important difference) in sexual domain scores from own baseline scores at 3 and 24 months post-treatment
| Variables | 3 months after radiation therapy | 24 months after radiation therapy | ||||
|---|---|---|---|---|---|---|
| Analysis | ||||||
| Univariate | Multivariate | Univariate | Multivariate | |||
| P | OR (95% CI) | P | P | OR (95% CI) | P | |
| Age | <0.01 | 1.00 (0.96–1.05) | 0.93 | 0.01 | 1.06 (1.01–1.11) | 0.025 |
| Prostate volume | <0.01 | 1.03 (1.01–1.06) | 0.009 | 0.42 | 1.03 (1.002–1.05) | 0.037 |
| NCCN risk classification | ||||||
| Low | Ref | Ref | Ref | Ref | ||
| Intermediate | 0.04 | 1.74 (0.88–3.46) | 0.11 | 0.68 | 0.92 (0.47–1.78) | 0.8 |
| High | <0.01 | 1.34 (0.45–3.99) | 0.6 | 0.07 | 0.90 (0.31–2.63) | 0.84 |
| ADT | ||||||
| No | Ref | Ref | Ref | Ref | ||
| Neo | 0.49 | 1.23 (0.61–2.46) | 0.56 | 0.04 | 0.55 (0.28–1.08) | 0.08 |
| Neo+adjuvant | 0.17 | 2.49 (0.94–6.59) | 0.07 | 0.49 | 1.30 (0.49–3.42) | 0.6 |
| Radiation therapy | ||||||
| BT + 3D-CRT | Ref | Ref | Ref | Ref | ||
| IMRT | 0.15 | 0.92 (0.43–1.98) | 0.84 | <0.01 | 3.41 (1.71–6.82) | <0.001 |
| BT | 0.12 | 1.15 (0.59–2.24) | 0.69 | <0.01 | 1.26 (0.63–2.49) | 0.51 |
| Baseline domain | <0.01 | 1.10 (1.07–1.12) | <0.001 | <0.01 | 1.11 (1.08–1.14) | <0.001 |
IMRT = intensity-modulated radiation therapy, BT = brachytherapy, 3D-CRT = 3D conformal radiation therapy, NCCN = National Comprehensive Cancer Network, Qmax = maximum flow rate, PVR = post-void residual, ADT = androgen-deprivation therapy, Neo = neoadjuvant therapy, CI = confidence interval, OR = odds ratio.