Table 3.

Multivariate analyses for overall survival, PSA-FFS, Grade ≥2 late GU and GI toxicity

	Overall survival		PSA-FFS		Late GU toxicity		Late GI toxicity
	Hazard ratio	P	Hazard ratio	P	Hazard ratio	P	Hazard ratio	P
Age	2.73	0.02	0.89	0.68	1.90	0.17	1.27	0.49
(≥ vs <70 years)	(1.19–6.27)		(0.50–1.57)		(1.77–4.71)		(0.65–2.50)
Risk	1.62	0.26	2.66	0.005	1.09	0.86	1.15	0.71
(HR vs LR/IR)	(0.70–3.72)		(1.35–5.22)		(0.43–2.70)		(0.56–2.34)
ADT	3.22	0.13	1.12	0.81	1.32	0.72	4.33	0.15
(Yes vs no)	(0.71–14.51)		(0.43–2.96)		(0.30–5.81)		(0.59–32.00)
Anticoagulant	1.66	0.23	0.51	0.13	1.62	0.33	2.03	0.06
(Yes vs no)	(0.73–3.81)		(0.21–1.22)		(0.61–4.26)		(0.97–4.24)
Coexistent DM	0.86	0.76	1.43	0.32	1.42	0.49	1.71	0.17
(Yes vs no)	(0.32–2.29)		(0.71–2.90)		(0.52–3.92)		(0.80–3.66)

LR, IR, HR = low, intermediate, and high risk, ADT = androgen deprivation therapy, DM = diabetes mellitus.