Table 2.
Genes related to neighborhood disadvantage and their functions
| Gene name | Function | |
|---|---|---|
| AVP [33] | Arginine vasopressin | Member of the vasopressin/oxytocin family; plays a role in glucocorticoid signaling, antidiuretic action on the kidney, and vasoconstriction of the peripheral vessels |
| BDNF [33] | Brain-derived neurotrophic factor | Plays a role in the regulation of the stress response and in the biology of mood disorders |
| CCL1 [33] | C-C motif chemokine ligand 1 | Small glycoprotein secreted by activated T cells that belongs to a family of inflammatory cytokines known as chemokines; has a role in cytokine and chemokine activity |
| CD1D [33] | CD1d molecule | Role in cell adhesion molecule binding |
| CRF [33] | Corticotropin-releasing factor | Major regulator of homeostasis, mediating the autonomic, behavioral, and neuroendocrine responses to stress |
| F8 [33] | Coagulation factor VIII | Acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa |
| FKBP5 [33] | FK506 binding protein 5 | Member of the immunophilin protein family; plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking |
| KLRG1 [33] | Killer cell lectin-like receptor G1 | Plays an inhibitory role on natural killer (NK) cells and T cell functions upon binding to their non-MHC ligands |
| MEG3 [35] | Maternally expressed 3 | RNA gene affiliated with the non-coding RNA class; inhibits tumor cell proliferation in vitro |
| NLRP12 [33] | NLR family pyrin domain containing 12 | NLRP12 is implicated in the activation of pro-inflammatory caspases (e.g., CASP1 = cysteine-type endopeptidase activator activity involved in apoptotic process). |
| SLAMF7 [33] | SLAM family member 7 | SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and are involved in the regulation and interconnection of both innate and adaptive immune responses. |
| SLC6A4 [33, 37] | Solute carrier family 6 member 4 | Sodium- and chloride-dependent members of the solute carrier family 6 encode an integral membrane protein, 5-HTT, that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner |
| TLR1 [33] | Toll-like receptor 1 | Single transmembrane cell-surface receptors; participates in the innate immune response to microbial agents; mediates the production of cytokines necessary for the development of effective immunity; leads to NF-kappa-B activation, cytokine secretion, and the inflammatory response |
Source: GeneCards. Human gene database retrieved from https://www.genecards.org