Figure 8.

Comparison of changes of candidate miRNAs expressions (W6‐W0) between clinical response patients and nonclinical response patients. MiR‐126‐5p level in knee OA patients was increased at W6 compared to W0, and its increase level in clinical responders was much larger than that in non‐clinical responders (B). MiRNA‐320a level was declined in non‐clinical responders while was increased in clinical responders (D). Conversely, miRNA‐146a‐5p level was increased in non‐clinical responders while was decreased in clinical responders (H). No difference of the expression of miR‐675‐3p (A), miR‐155‐5p (C), miR‐210 (E), miR‐3197 (F), miR‐17‐3p (G) (P = 0.606), miR‐4796 (I) (P = 0.950), or miR‐92a‐3p (J) (P = 0.515) was detected between clinical responders and nonclinical responders. Difference between clinical responders and nonclinical responders was determined by t test. P < 0.05 was considered statistically significant. OA, osteoarthritis; W, week