Table 1. Stability analysis of 111In-labeled 3-arm and 4-arm DOTA-α-MSH in plasma, liver, and kidney of mice by ex vivo.
Time (min) | 10 | 30 | 60 | 120 | 180 | |
---|---|---|---|---|---|---|
111In labeled 3-arm DOTA-α-MSH |
Plasma (%) | 96.1 ± 2.0 | 95.1 ± 1.8 | 86.4 ± 2.5 | 79.2 ± 2.2 | 73.5 ± 2.4 |
Liver (%) | 95.7 ± 2.1 | 95.5 ± 1.9 | 84.3 ± 2.2 | 71.6 ± 4.5 | 62.9 ± 6.7 | |
Kidney (%) | 95.8 ± 2.0 | 95.9 ± 1.7 | 85.7 ± 2.8 | 78.5 ± 2.7 | 74.3 ± 4.1 | |
111In labeled 4-arm DOTA-α-MSH |
Plasma (%) | 96.0 ± 2.5 | 95.8 ± 2.6 | 92.1 ± 2.1 | 84.2 ± 2.2 | 80.8 ± 2.3 |
Liver (%) | 95.1 ± 2.9 | 94.9 ± 2.1 | 91.3 ± 3.2 | 78.6 ± 4.9 | 76.2 ± 4.1 | |
Kidney (%) | 96.1 ± 2.0 | 95.8 ± 1.9 | 93.3 ± 3.5 | 84.5 ± 3.3 | 80.5 ± 2.8 |
All data are the mean ± standard deviation from triplicate measurements using three mice per time point