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. 2019 Mar 22;14(3):e0213397. doi: 10.1371/journal.pone.0213397

Table 1. Stability analysis of 111In-labeled 3-arm and 4-arm DOTA-α-MSH in plasma, liver, and kidney of mice by ex vivo.

Time (min) 10 30 60 120 180

111In labeled 3-arm DOTA-α-MSH
Plasma (%) 96.1 ± 2.0 95.1 ± 1.8 86.4 ± 2.5 79.2 ± 2.2 73.5 ± 2.4
Liver (%) 95.7 ± 2.1 95.5 ± 1.9 84.3 ± 2.2 71.6 ± 4.5 62.9 ± 6.7
Kidney (%) 95.8 ± 2.0 95.9 ± 1.7 85.7 ± 2.8 78.5 ± 2.7 74.3 ± 4.1

111In labeled 4-arm DOTA-α-MSH
Plasma (%) 96.0 ± 2.5 95.8 ± 2.6 92.1 ± 2.1 84.2 ± 2.2 80.8 ± 2.3
Liver (%) 95.1 ± 2.9 94.9 ± 2.1 91.3 ± 3.2 78.6 ± 4.9 76.2 ± 4.1
Kidney (%) 96.1 ± 2.0 95.8 ± 1.9 93.3 ± 3.5 84.5 ± 3.3 80.5 ± 2.8

All data are the mean ± standard deviation from triplicate measurements using three mice per time point