Table 2. Biological distribution of 111In-labeled 3-arm DOTA-α-MSH.
Organ (%ID/g or %ID/organ) |
10 min | 30 min | 60 min | 120 min | 180 min | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Brain | 0.04 | ± | 0.01 | 0.05 | ± | 0.02 | 0.05 | ± | 0.01 | 0.03 | ± | 0.00 | 0.02 | ± | 0.00 |
Lung | 0.51 | ± | 0.15 | 0.66 | ± | 0.24 | 0.31 | ± | 0.09 | 0.27 | ± | 0.09 | 0.10 | ± | 0.04 |
Heart | 0.74 | ± | 0.15 | 0.66 | ± | 0.13 | 0.46 | ± | 0.15 | 0.14 | ± | 0.06 | 0.06 | ± | 0.02 |
Stomach* | 0.06 | ± | 0.03 | 0.10 | ± | 0.03 | 0.12 | ± | 0.03 | 0.11 | ± | 0.05 | 0.12 | ± | 0.03 |
Liver | 2.30 | ± | 1.04 | 1.15 | ± | 0.92 | 1.12 | ± | 0.86 | 1.23 | ± | 0.47 | 0.72 | ± | 0.15 |
Small intestine* | 0.04 | ± | 0.03 | 0.08 | ± | 0.02 | 0.09 | ± | 0.03 | 0.12 | ± | 0.03 | 0.10 | ± | 0.03 |
Large intestine* | 0.03 | ± | 0.01 | 0.08 | ± | 0.02 | 0.09 | ± | 0.03 | 0.05 | ± | 0.03 | 0.04 | ± | 0.03 |
Kidney | 23.55 | ± | 3.63 | 18.42 | ± | 5.57 | 11.87 | ± | 5.40 | 8.42 | ± | 4.27 | 7.07 | ± | 3.02 |
Blood | 3.11 | ± | 0.84 | 1.91 | ± | 0.45 | 0.89 | ± | 0.22 | 0.21 | ± | 0.06 | 0.05 | ± | 0.02 |
Muscle | 0.21 | ± | 0.07 | 0.20 | ± | 0.08 | 0.15 | ± | 0.08 | 0.09 | ± | 0.04 | 0.05 | ± | 0.02 |
Melanoma | 1.71 | ± | 0.64 | 1.81 | ± | 0.45 | 2.49 | ± | 0.62 | 3.36 | ± | 0.90 | 3.51 | ± | 0.78 |
%ID/g indicates percent injected dose per gram of tissue.
*%ID/organ was calculated from %ID per organ. Values are the average ± standard deviation.
Values are the mean ± standard deviation obtained from three mice per time point.