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. 2019 Mar 22;14(3):e0213397. doi: 10.1371/journal.pone.0213397

Table 2. Biological distribution of 111In-labeled 3-arm DOTA-α-MSH.

Organ
(%ID/g or %ID/organ)
10 min 30 min 60 min 120 min 180 min
Brain 0.04 ± 0.01 0.05 ± 0.02 0.05 ± 0.01 0.03 ± 0.00 0.02 ± 0.00
Lung 0.51 ± 0.15 0.66 ± 0.24 0.31 ± 0.09 0.27 ± 0.09 0.10 ± 0.04
Heart 0.74 ± 0.15 0.66 ± 0.13 0.46 ± 0.15 0.14 ± 0.06 0.06 ± 0.02
Stomach* 0.06 ± 0.03 0.10 ± 0.03 0.12 ± 0.03 0.11 ± 0.05 0.12 ± 0.03
Liver 2.30 ± 1.04 1.15 ± 0.92 1.12 ± 0.86 1.23 ± 0.47 0.72 ± 0.15
Small intestine* 0.04 ± 0.03 0.08 ± 0.02 0.09 ± 0.03 0.12 ± 0.03 0.10 ± 0.03
Large intestine* 0.03 ± 0.01 0.08 ± 0.02 0.09 ± 0.03 0.05 ± 0.03 0.04 ± 0.03
Kidney 23.55 ± 3.63 18.42 ± 5.57 11.87 ± 5.40 8.42 ± 4.27 7.07 ± 3.02
Blood 3.11 ± 0.84 1.91 ± 0.45 0.89 ± 0.22 0.21 ± 0.06 0.05 ± 0.02
Muscle 0.21 ± 0.07 0.20 ± 0.08 0.15 ± 0.08 0.09 ± 0.04 0.05 ± 0.02
Melanoma 1.71 ± 0.64 1.81 ± 0.45 2.49 ± 0.62 3.36 ± 0.90 3.51 ± 0.78

%ID/g indicates percent injected dose per gram of tissue.

*%ID/organ was calculated from %ID per organ. Values are the average ± standard deviation.

Values are the mean ± standard deviation obtained from three mice per time point.