Table 1. Patients’ characteristics.
| Arm A (active arm) |
Arm B (observational arm) | |
|---|---|---|
| Number of patients | (n = 29) | (n = 32) |
| Age in years | ||
| Mean ± SD Median (range) |
16.97 ± 12.19 14.5 (2.6–45.2) |
17.19 ± 12.74 13.6 (2.4–50.7) |
| Gender | ||
| Male | 20 (69.0%) | 15 (46.9%) |
| Female | 9 (31.0%) | 17 (53.1%) |
| CFTR genotype | ||
| F508del homozygotes | 7 (24.1%) | 6 (18.8%) |
| F508del heterozygotes | 13 (44.9%) | 16 (50.0%) |
| Other genotype | 9 (31.0%) | 10 (31.2%) |
| Anthropometrics (mean ± SD) | ||
| Weight (kgs) | 45.15 ± 21.85 | 41.84 ± 20.09 |
| Height (cm) | 146.64 ± 27.02 | 142.95 ± 26.48 |
| BMI (Kg/m2) | 19.18 ± 3.92 | 18.75 ± 4.11 |
| Spirometry | ||
| FEV1 (L) | 2.20 ± 0.97 | 2.05 ± 0.87 |
| FEV1 (% of predicted) | 78.13 ± 24.70 | 81.95 ± 27.31 |
| FEV1 groups | ||
| ≥ 70 | 16 (55.2%) | 21 (65.6%) |
| < 70 | 8 (27.6%) | 7 (21.9%) |
| Unable to perform spirometry | 5 (17.2%) | 4 (12.5%) |
| First MRSA infection | 26 (89.7%) | 29 (90.6%) |
| Previously infected | 3 (10.3%) | 3 (9.4%) |
| Sampling methods | ||
| Throat swabs | 7 (24.1%) | 5 (15.6%) |
| Sputum | 22 (75.9%) | 27 (84.4%) |
| Patients’ microbiological status for other pathogens at baseline | ||
| Methicillin-sensitive Staphylococcus aureus (MSSA) | ||
| Positive | 10 (34.5%) | 12 (37.5%) |
| Negative | 19 (65.5%) | 20 (62.5%) |
| P. aeruginosa | ||
| Positive [chronic] | 12 (41.4%) [6] | 17 (53.1%) [4] |
| Negative | 17 (58.6%) | 15 (46.9%) |
| A. xylosoxidans | ||
| Positive | 1 (3.4%) | 1 (3.1%) |
| Negative | 28 (96.6%) | 31 (96.9%) |
| S. maltophilia | ||
| Positive | 1 (3.4%) | 4 (12.5%) |
| Negative | 28 (96.6%) | 28 (87.5%) |
| Aspergillus spp | ||
| Positive | 0 (0%) | 5 (15.6%) |
| Negative | 29 (100%) | 27 (84.4%) |
| Other | ||
| 6 (20.7%) | 11 (34.4%) | |
| 4 with H. influenzae | 9 with H. influenzae | |
| 2 with B. gladioli | 2 with nontuberculous mycobacteria | |