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. 2019 Mar 6;71(4):550–560. doi: 10.1002/art.40749

Figure 1.

Figure 1

Whole‐brain analysis and region of interest analysis results of punctate stimulation. A, Mixed‐effects, whole‐brain analysis comparing responses to punctate stimulation between the neuropathic‐like pain group (n = 14) and the nociceptive pain group (n = 10). Correlation between the change in blood oxygen level–dependent (BOLD) signal activity in the rostral anterior cingulate cortex (rACC) and the severity of neuropathic‐like pain symptoms is shown. Significantly increased activity in the nociceptive pain group compared to the neuropathic‐like pain group is indicated (red), and a functional mask was generated using a 5‐mm sphere from the peak voxel of activation in the rACC cluster (yellow). There were no areas in which activation was significantly higher in the neuropathic‐like pain group than in the nociceptive pain group. Whole‐brain analyses were corrected for multiple comparisons (Z score >2.3, P < 0.05). B, Region of interest analysis comparing responses (n = 24) to punctate stimulation between the neuropathic‐like pain group (n = 14) and the nociceptive pain group (n = 10). Correlation between the change in BOLD signal activity in the rostral ventromedial medulla (RVM) and the severity of neuropathic‐like pain symptoms is shown. Region of interest test statistics were generated from a generalized linear model design, thresholded using threshold‐free cluster enhancement. P < 0.05. Images are displayed in radiologic convention with Montreal Neurological Institute coordinates given.