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. 2018 Nov 8;52(1):e12526. doi: 10.1111/cpr.12526

Figure 5.

Figure 5

NEAT1 knockdown counteracted the tumour promoting effects of miR‐193a inhibitor in CRC cells. A, B, MTT and cell colony formation assays showed that miR‐193a inhibitor increased cell proliferative activity and colony formation capacity, but these tumour promoting effects induced by miR‐193a were attenuated by NEAT1 knockdown in LOVO and HCT116 cell lines. C, TCGA data analysis of the expression level of IL17RD in pared CRC samples. D, TCGA data analysis of the correlation of IL17RD expression with miR‐193a in CRC samples. E, qRT‐PCR and Western blot analysis of the effects of lncRNA NEAT1 on the expression of IL17RD. F, G, qRT‐PCR and Western blot analysis showed that miR‐193a inhibitor increased the expression of IL17RD and this effect was reversed by NEAT1 knockdown in LOVO and HCT116 cell lines. * P < 0.05; ** P < 0.01