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. 2018 Oct 17;52(1):e12529. doi: 10.1111/cpr.12529

Figure 6.

Figure 6

The working model for Cno‐mediated effects on cell proliferation. A, Overexpression of cno simultaneously activates JNK and Ras‐MAPK signalling, inducing both cell proliferation and cell death. B, Moderately reducing the activation levels of JNK signalling suppresses the effect of Cno on cell death, inducing massive cell overproliferation via Hippo signalling