Figure 6.

Progressive disease in bone in the subgroup of patients with bone metastases at baseline (n = 556). Progressive disease in bone (first documented progression event in bone, with or without concurrent progression outside of bone) was defined as unequivocal progression of a preexisting bone lesion or the appearance of a new bone lesion at the time of documented progressive disease as assessed by the investigator at the local site. Comparison of cumulative incidence of progression due to bone metastasis using competing risk method by treatment for subgroup of patients who had bone metastasis at baseline; P = .02 (Gray’s test, 2-sided). CI = confidence interval; CR = competing risk estimate.