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. 2018 Jun 27;140(29):9299–9313. doi: 10.1021/jacs.8b05807

Table 2. Thermodynamic Binding Parameters of Peptides 13a–c and Ligands 14a,b to VBC.

  Kd (nM) ΔH (kcal/mol) –TΔS (kcal/mol) ΔG (kcal/mol) N.R.a
13a 12 ± 2 –10.1 ± 0.1 –0.75 ± 0.05 –10.8 ± 0.1 2
13b 52 ± 3 –9.7 ± 0.3 0.0 ± 0.2 –9.94 ± 0.04 2
13c 11 ± 1 –12.8 ± 0.1 2.0 ± 0.2 –10.9 ± 0.1 2
14a 244 ± 6 –7.2 ± 0.5 –1.8 ± 0.5 –9.02 ± 0.01 3
14b 3,080 ± 10 –3.9 ± 0.5 –3.8 ± 0.4 –7.55 ± 0.03 2
a

N.R. = number of replicates.