. 2018 Jun 27;140(29):9299–9313. doi: 10.1021/jacs.8b05807

Table 3. Cellular Pharmacokinetics Parameters of VHL Ligands 14a,b.

	mouse microsomal stability (mL/min/g liver)	plasma stability T_1/2 (min)	permeability (PAMPA) (nm s^–1)	CHI LogD_7.4
VH032	0.70^a	>180^a	1.2^a	0.90^a
14a	<0.50	>180	2.3	1.30
14b	0.68	>180	0.81	1.30

Values from Frost et al.⁴⁰